RGD Reference Report - Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat.

Authors: St. Lezin, E  Liu, W  Wang, JM  Wang, N  Kren, V  Krenova, D  Musilova, A  Zdobinska, M  Zidek, V  Lau, D  Pravenec, M 
Citation: St. Lezin E, etal., Hypertension 1997 Oct;30(4):854-9
RGD ID: 61048
Pubmed: PMID:9336384   (View Abstract at PubMed)

Recent linkage studies in the spontaneously hypertensive rat (SHR) suggest that a blood pressure regulatory gene or genes may be located on rat chromosome 1q. To investigate this possibility, we replaced a region of chromosome 1 in the SHR (defined by the markers D1Mit3 and Igf2) with the corresponding chromosome segment from the normotensive Brown-Norway (BN) strain. In male SHR congenic rats carrying the transferred BN chromosome segment, 24-hour average systolic and diastolic blood pressures were significantly lower than in male progenitor SHR. Polymerase chain reaction genotyping using 60 polymorphic microsatellite markers dispersed throughout the genome confirmed the congenic status of the new strain designated SHR.BN-D1Mit3/Igf2. These findings provide direct evidence that a blood pressure regulatory gene exists on the differential segment of chromosome 1 that is sufficient to decrease blood pressure in the SHR. The SHR.BN-D1Mit3/Igf2 congenic strain represents an important new model for fine mapping and characterization of genes on chromosome 1 involved in the pathogenesis of spontaneous hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp26Rathypertension  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHR.BN-(D1Mit3-Igf2)/IpcvRatdecreased systemic arterial diastolic blood pressure  IAGP compared to SHR/Ola strainRGD 
SHR.BN-(D1Mit3-Igf2)/IpcvRatdecreased systemic arterial systolic blood pressure  IAGP compared to SHR/Ola strainRGD 
Bp26Ratincreased systemic arterial blood pressure  IAGP  RGD 
Objects Annotated

QTLs
Bp26  (Blood pressure QTL 26)

Strains
BN/Crl  (NA)
SHR.BN-(D1Mit3-Igf2)/Ipcv  (NA)
SHR/Ola  (NA)

Objects referenced in this article
Marker D1Mit3 D1Mit3 Rattus norvegicus
QTL Bp28 Blood pressure QTL 28 Rattus norvegicus
QTL Bp29 Blood pressure QTL 29 Rattus norvegicus
QTL Bp30 Blood pressure QTL 30 Rattus norvegicus
Gene Igf2 insulin-like growth factor 2 Rattus norvegicus

Additional Information