RGD Reference Report - A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. - Rat Genome Database

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A biometrical genome search in rats reveals the multigenic basis of blood pressure variation.

Authors: Schork, NJ  Krieger, JE  Trolliet, MR  Franchini, KG  Koike, G  Krieger, EM  Lander, ES  Dzau, VJ  Jacob, HJ 
Citation: Schork NJ, etal., Genome Res 1995 Sep;5(2):164-72
RGD ID: 61045
Pubmed: (View Article at PubMed) PMID:9132270

A genome-wide search for multiple loci influencing salt-loaded systolic blood pressure (NaSBP) variation among 188 F2 progeny from a cross between the Brown-Norway and spontaneously hypertensive rat strains was pursued in an effort to gain insight into the polygenic basis of blood pressure regulation. The results suggest that loci within five to six genomic regions collectively explain approximately 43% of the total NaSBP variation exhibited among the 188 F2 progeny. Many of these loci are in regions that previous studies have not implicated in blood pressure regulation. Ultimately, however, this study not only sheds light on the multigenic basis of blood pressure but provides further evidence that the identification of the genetic determinants of polygenic traits in mammals is possible with modern biometrical and molecular genetic tools in controlled settings (i.e., breeding paradigm and model organism).

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp18  (Blood pressure QTL 18)
Bp19  (Blood pressure QTL 19)
Bp20  (Blood pressure QTL 20)
Bp21  (Blood pressure QTL 21)
Bp22  (Blood pressure QTL 22)
Bp23  (Blood pressure QTL 23)

Objects referenced in this article
Marker D8Mit5 D8Mit5 Rattus norvegicus
Marker D16Mit5 D16Mit5 Rattus norvegicus
Marker D4Mit2 D4Mit2 Rattus norvegicus
Marker D3Mit2 D3Mit2 Rattus norvegicus
Marker D16Mit2 D16Mit2 Rattus norvegicus
Marker D8Mit3 D8Mit3 Rattus norvegicus
Marker D2Mgh14 D2Mgh14 Rattus norvegicus
Marker D2Mgh8 D2Mgh8 Rattus norvegicus
Marker D3Mgh2 D3Mgh2 Rattus norvegicus
Strain BN BN Rattus norvegicus
QTL Bp16 Blood pressure QTL 16 Rattus norvegicus
QTL Bp39 Blood pressure QTL 39 Rattus norvegicus
Gene Mt1-ps2 metallothionein 1, pseudogene 2 Rattus norvegicus
Gene Npr1 natriuretic peptide receptor 1 Rattus norvegicus
Gene Npy neuropeptide Y Rattus norvegicus
Strain SHR Spontaneously Hypertensive Rat Rattus norvegicus

Additional Information