RGD Reference Report - Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. - Rat Genome Database

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Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.

Authors: Pravenec, M  Gauguier, D  Schott, JJ  Buard, J  Kren, V  Bila, V  Szpirer, C  Szpirer, J  Wang, JM  Uang H, H  Et, AL 
Citation: Pravenec M, etal., J Clin Invest 1995 Oct;96(4):1973-8
RGD ID: 61044
Pubmed: (View Article at PubMed) PMID:7560090
DOI: Full-text: DOI:10.1172/JCI118244

In the HXB and BXH recombinant inbred strains derived from the spontaneously hypertensive rat and the normotensive Brown Norway rat, we determined the strain distribution patterns of 500 genetic markers to scan the rodent genome for quantitative trait loci regulating cardiac mass and blood pressure. The markers spanned approximately 1,139 cM of the genome and were tested for correlations with left ventricular mass adjusted for body weight, and with systolic, diastolic, and mean arterial pressures. The marker for the dopamine 1A receptor (Drd1a) on chromosome 17 showed the strongest correlation with left ventricular heart weight (P = .00038, r = -0.59) and the relationship to heart weight was independent of blood pressure. The markers showing the strongest correlations with systolic, diastolic, and mean arterial pressure were D19Mit7 on chromosome 19 (P = .0012, r = .55), D2N35 on chromosome 2 (P = .0008, r = .56), and Il6 on chromosome 4 (P = .0018, r = .53), respectively. These studies demonstrate that the HXB and BXH strains can be effectively used for genome scanning studies of complex traits and have revealed several chromosome regions that may be involved in the genetic control of blood pressure and cardiac mass in the rat.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp32  (Blood pressure QTL 32)
Bp33  (Blood pressure QTL 33)

Objects referenced in this article
Marker D19Mit7 D19Mit7 Rattus norvegicus
Marker D2N35 D2N35 Rattus norvegicus
Gene Bcl2 BCL2, apoptosis regulator Rattus norvegicus
Strain BN BN Rattus norvegicus
Strain BXH/Ipcv null Rattus norvegicus
Strain HXB/Ipcv null Rattus norvegicus
Gene Il16 interleukin 16 Rattus norvegicus
Gene Jun Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
Strain SHR Spontaneously Hypertensive Rat Rattus norvegicus

Additional Information