RGD Reference Report - Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect. - Rat Genome Database

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Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect.

Authors: Samani, NJ  Gauguier, D  Vincent, M  Kaiser, MA  Bihoreau, MT  Lodwick, D  Wallis, R  Parent, V  Kimber, P  Rattray, F  Thompson, JR  Sassard, J  Lathrop, M 
Citation: Samani NJ, etal., Hypertension 1996 Dec;28(6):1118-22
RGD ID: 61043
Pubmed: (View Article at PubMed) PMID:8952608

Previous studies have suggested the presence of quantitative trait loci (QTLs) influencing blood pressure on rat chromosomes 2 and 13. In this study, we mapped the QTLs in F2 rats derived from a cross of the spontaneously hypertensive rat and the Wistar-Kyoto rat and analyzed the effect of the QTLs on blood pressures measured longitudinally between 12 and 25 weeks of age. We analyzed 16 polymorphic markers spanning 147.3 cM on chromosome 2 and 13 markers spanning 91.6 cM on chromosome 13. Both chromosomes contained QTLs with highly significant effects on blood pressure (peak logarithm of the odds [LOD] scores, 5.64 and 5.75, respectively). On chromosome 2, the peak was localized to a position at anonymous marker D2Wox7, 2.9 cM away from the gene for the sodium-potassium ATPase alpha 1-subunit. On chromosome 13, the major peak coincided with the marker D13Mit2, 21.7 cM away from the renin gene, but there was a suggestion of multiple peaks. The effect of the QTL on chromosome 2 was seen throughout from 12 to 25 weeks of age, whereas interestingly, the effect for the QTL on chromosome 13 was maximal at 20 weeks of age but disappeared at 25 weeks of age, presumably because of the effect of either epistatic factors or environmental influences. The findings provide important information on QTLs influencing blood pressure on rat chromosomes 2 and 13 that will be useful in localizing and identifying the causative genes and emphasize the importance of age being taken into account when the effects of individual QTLs on a trait that shows significant age-related changes are being analyzed.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp16  (Blood pressure QTL 16)
Bp31  (Blood pressure QTL 31)
Bp55  (Blood pressure QTL 55)
Bp63  (Blood pressure QTL 63)

Objects referenced in this article
0 D13Mit2 D13Mit2 All species
0 D2Wox7 D2Wox7 All species
0 D13Kyo3 D13Kyo3 All species
0 Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 All species
0 Bp25 Blood pressure QTL 25 All species
0 SHR Spontaneously Hypertensive Rat All species
0 WKY null All species

Additional Information