RGD Reference Report - Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. - Rat Genome Database

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Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

Authors: Deng, AY  Dene, H  Rapp, JP 
Citation: Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
RGD ID: 61038
Pubmed: (View Article at PubMed) PMID:8040284
DOI: Full-text: DOI:10.1172/JCI117341

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp10  (Blood pressure QTL 10)
Bp158  (Blood pressure QTL 158)

Objects referenced in this article
Gene Agtr1b angiotensin II receptor, type 1b Rattus norvegicus
Gene Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 Rattus norvegicus
Gene Camk2d calcium/calmodulin-dependent protein kinase II delta Rattus norvegicus
Gene Fgg fibrinogen gamma chain Rattus norvegicus
Gene Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 Rattus norvegicus
Gene Mme membrane metallo-endopeptidase Rattus norvegicus
Strain MNS Milan normotensive strain Rattus norvegicus
Gene Npr1 natriuretic peptide receptor 1 Rattus norvegicus
Gene Prlr prolactin receptor Rattus norvegicus
Strain SS/Jr Salt Sensitive Rattus norvegicus
Strain WKY null Rattus norvegicus

Additional Information