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Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

Authors: Deng, AY  Dene, H  Rapp, JP 
Citation: Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
Pubmed: (View Article at PubMed) PMID:8040284
DOI: Full-text: DOI:10.1172/JCI117341

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.


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RGD Object Information
RGD ID: 61038
Created: 2000-12-21
Species: All species
Last Modified: 2001-12-18
Status: ACTIVE


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