RGD Reference Report - Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. - Rat Genome Database

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Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.

Authors: Kawahito, Y  Cannon, GW  Gulko, PS  Remmers, EF  Longman, RE  Reese, VR  Wang, J  Griffiths, MM  Wilder, RL 
Citation: Kawahito Y, etal., J Immunol 1998 Oct 15;161(8):4411-9
RGD ID: 61035
Pubmed: (View Article at PubMed) PMID:9780220

Adjuvant-induced arthritis (AIA) in rats is a widely used autoimmune experimental model with many features similar to rheumatoid arthritis (RA). To identify potential genetic regulatory mechanisms in RA, we conducted genome-wide linkage analysis in F2 progeny of arthritis-susceptible Dark Agouti (DA) and relatively resistant Fischer 344 (F344) inbred rats. We compared the data with our previously reported investigation of collagen-induced arthritis (CIA), which was expanded in the follow-up study reported in this work. We found two quantitative trait loci (QTLs) in common, i.e., Aia1/Cia1 on chromosome 20, which includes the MHC, and Aia3/Cia3 on chromosome 4. We also identified a second unique QTL in AIA, Aia2, on chromosome 4. Interestingly, the QTL region on chromosome 4 (Aia3/Cia3), like the MHC, appears to be involved in several other autoimmune diseases in rats, including insulin-dependent diabetes, thyroiditis, and experimental autoimmune uveitis. Moreover, an analysis of conserved synteny among rats, mice, and humans suggested that Aia2 and Aia3/Cia3, like Aia1/Cia1, contain candidate genes for several autoimmune/inflammatory diseases in mice and humans, including diabetes, systemic lupus erythematosus, inflammatory bowel disease, asthma/atopy, multiple sclerosis, and RA. The rat models appear to provide a powerful complementary approach to identify and characterize candidate genes that may contribute to autoimmune diseases in several species.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Aia1  (Adjuvant induced arthritis QTL 1)
Aia2  (Adjuvant induced arthritis QTL 2)
Aia3  (Adjuvant induced arthritis QTL 3)
Aia4  (Adjuvant induced arthritis QTL 4)
Bp79  (Blood pressure QTL 79)

Objects referenced in this article
0 D4Arb16 D4Arb16 All species
0 D20Arb2 D20Arb2 All species
0 D20Wox3 D20Wox3 All species
0 D15Mit6 D15Mit6 All species
0 D4Mgh15 D4Mgh15 All species
0 D15Mgh3 D15Mgh3 All species
0 D15Rat22 D15Rat22 All species
0 D4Arb26 D4Arb26 All species
0 D4Arb30 D4Arb30 All species
0 D4Arb24 D4Arb24 All species
0 D20Arb8 D20Arb8 All species
0 Cia1 Collagen induced arthritis QTL 1 All species
0 DA DA All species
0 Eau1 Experimental allergic uveoretinitis QTL 1 All species
0 F344/NRrrc null All species
0 Iddm4 Insulin dependent diabetes mellitus QTL 4 All species
0 Npy neuropeptide Y All species
0 Pia1 Pristane induced arthritis QTL 1 All species
0 Pia2 Pristane induced arthritis QTL 2 All species
0 Tcrb T-cell receptor beta chain All species

Additional Information