RGD Reference Report - Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice. - Rat Genome Database

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Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice.

Authors: Xu, Zheng  Wang, Can  Dong, Xiaoguang  Hu, Tao  Wang, Lingling  Zhao, Wenbo  Zhu, Shaowei  Li, Guibao  Hu, Yanlai  Gao, Qing  Wan, Jiale  Liu, Zengxun  Sun, Jinhao 
Citation: Xu Z, etal., Biofactors. 2019 Mar;45(2):187-199. doi: 10.1002/biof.1469. Epub 2018 Nov 12.
RGD ID: 596938163
Pubmed: PMID:30417952   (View Abstract at PubMed)
DOI: DOI:10.1002/biof.1469   (Journal Full-text)

Alcohol addiction can cause brain dysfunction and many other diseases. Recently, increasing evidences have suggested that gut microbiota plays a vital role in regulating alcohol addiction. However, the exact mechanism has not yet been elucidated. Here, our study focused on the intestinal bacteria alternations and their correlations with alcohol-induced neuropsychic behaviors. When consuming alcohol over 3-week period, animals gradually displayed anxiety/depression-like behaviors. Moreover, 16S rRNA sequencing showed significant intestinal microflora dysbiosis and distinct community composition. Actinobacteria and Cyanobacteria were both increased at the phylum level. At the genus level, Adlercreutzia spp., Allobaculum spp., and Turicibacter spp. were increased whereas Helicobacter spp. was decreased. We also found that the distances in inner zone measured by open field test and 4% (v/v) alcohol preference percentages were significantly correlated with Adlercreutzia spp. The possible mechanisms were explored and we found the expression of brain-derived neurotrophic factor (BDNF) and α1 subunit of γ-aminobutyric acid A receptor (Gabra1) were both decreased in prefrontal cortex (PFC). Especially, further correlation analyses demonstrated that decreased Adlercreutzia spp. was positively correlated with alcohol preference and negatively correlated with anxiety-like behavior and BDNF/Gabra1 changes in PFC. Similar relationships were observed between Allobaculum spp. and alcohol preference and BDNF changes. Helicobacter spp. and Turicibacter spp. were also correlated with PFC BDNF and hippocampus Gabra1 level. Taken together, our study showed that gut microbiota dysbiosis during chronic alcohol exposure was closely correlated with alcohol-induced neuropsychic behaviors and BDNF/Gabra1 expression, which provides a new perspective for understanding underlying mechanisms in alcohol addiction. © 2018 BioFactors, 45(2):187-199, 2019.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BDNFHumanDysbiosis  ISOBdnf (Mus musculus)associated with alcohol dependence more ...RGD 
BdnfRatDysbiosis  ISOBdnf (Mus musculus)associated with alcohol dependence more ...RGD 
BdnfMouseDysbiosis  IEP associated with alcohol dependence more ...RGD 
GABRA1HumanDysbiosis  ISOGabra1 (Mus musculus)associated with alcohol dependence and mRNA:decreased expression:hippocampusRGD 
Gabra1RatDysbiosis  ISOGabra1 (Mus musculus)associated with alcohol dependence and mRNA:decreased expression:hippocampusRGD 
Gabra1MouseDysbiosis  IEP associated with alcohol dependence and mRNA:decreased expression:hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)
Gabra1  (gamma-aminobutyric acid type A receptor subunit alpha 1)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)
Gabra1  (gamma-aminobutyric acid type A receptor subunit alpha 1)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)
GABRA1  (gamma-aminobutyric acid type A receptor subunit alpha1)


Additional Information