RGD Reference Report - Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. - Rat Genome Database

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Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.

Authors: Lee, SH  Lee, JW  Kim, HS  Kim, SY  Park, WS  Kim, SH  Lee, JY  Yoo, NJ 
Citation: Lee SH, etal., APMIS. 2003 May;111(5):586-90.
RGD ID: 5688748
Pubmed: PMID:12887511   (View Abstract at PubMed)

The serine protease Omi/HtrA2 is released from mitochondria into the cytosol after apoptosis stimuli, inducing apoptosis in a caspase-independent manner through its protease activity and in a caspase-dependent manner by neutralizing the inhibition of inhibitor of apoptosis proteins (IAPs) on caspases. Alteration of apoptosis is essential for cancer development, and cancer cell death by radiation and chemotherapy is largely dependent upon apoptosis. Thus, analysis of the expression status of Omi/HtrA2, a regulator of apoptosis, in cancer tissues is needed for an understanding of cancer development. In the current study, we analyzed the expression of Omi/HtrA2 in 60 advanced gastric adenocarcinomas by immunohistochemistry using a tissue microarray approach. Immunopositivity (defined as >/=30%) was observed for Omi/HtrA2 in 43 (72%) of the 60 cancers. By contrast, the surface mucous cells and mucous neck cells in the normal gastric mucosa showed no or weak expression of Omi/HtrA2. Taken together, these results suggest that stomach cancer cells in vivo may need Omi/HtrA2 expression for apoptosis, and that Omi/HtrA2 expression might be involved in stomach cancer development.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
stomach cancer  IEP 5688748protein:increased expression:gastric mucosa (human)RGD 
stomach cancer  ISOHTRA2 (Homo sapiens)5688748; 5688748protein:increased expression:gastric mucosa (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htra2  (HtrA serine peptidase 2)

Genes (Mus musculus)
Htra2  (HtrA serine peptidase 2)

Genes (Homo sapiens)
HTRA2  (HtrA serine peptidase 2)


Additional Information