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Asiatic acid protects primary neurons against C(2)-ceramide-induced apoptosis.

Authors: Zhang, X  Wu, J  Dou, Y  Xia, B  Rong, W  Rimbach, G  Lou, Y 
Citation: Zhang X, etal., Eur J Pharmacol. 2012 Mar 15;679(1-3):51-9. Epub 2012 Jan 24.
Pubmed: (View Article at PubMed) PMID:22296759
DOI: Full-text: DOI:10.1016/j.ejphar.2012.01.006

Ceramides derived from sphingosine contribute to the apoptotic processes of neuronal cells in neurodegenerative disorders including Alzheimer's disease. This study investigates the potential neuroprotective effects of Asiatic acid, a triterpenoid derived from Centella asiatica, against C(2)-ceramides-induced cell death in primary cultured rat cortical neuronal cells. In primary neurons, Asiatic acid (0.01 to 1.0mumol/l) reduced C(2)-ceramide-induced cell death and mitochondria membrane potential loss in a concentration-dependent manner. Furthermore, Asiatic acid decreased cellular production of reactive oxygen species following C(2)-ceramide treatment. At a maximal concentration of 1.0mumol/l, Asiatic acid partly counteracted the pro-apoptotic effects of the C(2)-ceramide by reducing the cytosolic release of HtrA2/Omi, the upregulation of Bax and caspase 3, as well as the dephosphorlyation of ERK1/2. Taken together, these data suggest that Asiatic acid protects neurons from C(2)-ceramide-induced cell death by antagonizing mitochondria-dependent apoptosis.


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RGD ID: 5688365
Created: 2012-02-29
Species: All species
Last Modified: 2012-02-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.