RGD Reference Report - Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. - Rat Genome Database

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Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study.

Authors: Smith, SB  Maixner, DW  Greenspan, JD  Dubner, R  Fillingim, RB  Ohrbach, R  Knott, C  Slade, GD  Bair, E  Gibson, DG  Zaykin, DV  Weir, BS  Maixner, W  Diatchenko, L 
Citation: Smith SB, etal., J Pain. 2011 Nov;12(11 Suppl):T92-101.
RGD ID: 5688353
Pubmed: PMID:22074755   (View Abstract at PubMed)
PMCID: PMC3268684   (View Article at PubMed Central)
DOI: DOI:10.1016/j.jpain.2011.08.005   (Journal Full-text)

Genetic factors play a role in the etiology of persistent pain conditions, putatively by modulating underlying processes such as nociceptive sensitivity, psychological well-being, inflammation, and autonomic response. However, to date, only a few genes have been associated with temporomandibular disorders (TMD). This study evaluated 358 genes involved in pain processes, comparing allelic frequencies between 166 cases with chronic TMD and 1,442 controls enrolled in the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) study cooperative agreement. To enhance statistical power, 182 TMD cases and 170 controls from a similar study were included in the analysis. Genotyping was performed using the Pain Research Panel, an Affymetrix gene chip representing 3,295 single nucleotide polymorphisms, including ancestry-informative markers that were used to adjust for population stratification. Adjusted associations between genetic markers and TMD case status were evaluated using logistic regression. The OPPERA findings provided evidence supporting previously reported associations between TMD and 2 genes: HTR2A and COMT. Other genes were revealed as potential new genetic risk factors for TMD, including NR3C1, CAMK4, CHRM2, IFRD1, and GRK5. While these findings need to be replicated in independent cohorts, the genes potentially represent important markers of risk for TMD, and they identify potential targets for therapeutic intervention. PERSPECTIVE: Genetic risk factors for TMD pain were explored in the case-control component of the OPPERA cooperative agreement, a large population-based prospective cohort study. Over 350 candidate pain genes were assessed using a candidate gene panel, with several genes displaying preliminary evidence for association with TMD status.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Temporomandibular Joint Disorders  IAGP 5688353DNA: SNP: rs12415832RGD 
Temporomandibular Joint Disorders  ISOGRK5 (Homo sapiens)5688353; 5688353DNA: SNP: rs12415832RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grk5  (G protein-coupled receptor kinase 5)

Genes (Mus musculus)
Grk5  (G protein-coupled receptor kinase 5)

Genes (Homo sapiens)
GRK5  (G protein-coupled receptor kinase 5)


Additional Information