RGD Reference Report - 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. - Rat Genome Database

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15d-prostaglandin J2 protects brain from ischemia-reperfusion injury.

Authors: Lin, TN  Cheung, WM  Wu, JS  Chen, JJ  Lin, H 
Citation: Lin TN, etal., Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):481-7. Epub 2005 Dec 29.
RGD ID: 5688223
Pubmed: PMID:16385084   (View Abstract at PubMed)

OBJECTIVE: Brain expresses abundant lipocalin-type prostaglandin (PG) D2 (PGD2) synthase but the role of PGD2 and its metabolite, 15-deoxy-Delta(12,14) PGJ2 (15d-PGJ2) in brain protection is unclear. The aim of this study is to assess the effect of 15d-PGJ2 on neuroprotection. METHODS AND RESULTS: Adenoviral transfer of cyclooxygenase-1 (Adv-COX-1) was used to amplify the production of 15d-PGJ2 in ischemic cortex in a rat focal infarction model. Cortical 15d-PGJ2 in Adv-COX-1-treated rats was increased by 3-fold over control, which was correlated with reduced infarct volume and activated caspase 3, and increased peroxisome proliferator activated receptor-gamma (PPARgamma) and heme oxygenase-1 (HO-1). Intraventricular infusion of 15d-PGJ2 resulted in reduction of infarct volume, which was abrogated by a PPARgamma inhibitor. Rosiglitazone infusion had a similar effect. 15d-PGJ2 and rosiglitazone at low concentrations suppressed H2O2-induced rat or human neuronal apoptosis and necrosis and induced PPARgamma and HO-1 expression. The anti-apoptotic effect was abrogated by PPARgamma inhibition. CONCLUSIONS: 15d-PGJ2 suppressed ischemic brain infarction and neuronal apoptosis and necrosis in a PPARgamma dependent manner. 15d-PGJ2 may play a role in controlling acute brain damage induced by ischemia-reperfusion.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Reperfusion Injury  IDA 5688223 RGD 
Reperfusion Injury  ISOPTGS1 (Homo sapiens)5688223; 5688223 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)

Genes (Mus musculus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)

Genes (Homo sapiens)
PTGS1  (prostaglandin-endoperoxide synthase 1)


Additional Information