RGD Reference Report - Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats. - Rat Genome Database

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Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats.

Authors: Bajgar, J 
Citation: Bajgar J Acta Medica (Hradec Kralove). 2008;51(4):223-8.
RGD ID: 5688054
Pubmed: PMID:19453088   (View Abstract at PubMed)

The protective effect of the reversible cholinesterase inhibitors tacrine and pyridostigmine alone or in combination with different drugs against acetylcholinesterase inhibition in the pontomedullar area and cerebellum of rats caused by VX agent (O-ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate) in vivo (2xLD50) was studied along with survival of animals pretreated with different combinations of the drugs used. The best prophylactic effect was observed in a combination of pyridostigmine with benactyzine, trihexyphenidyle and HI-6. Tacrine alone or in other combinations has had no better prophylactic effect in comparison with these combinations containing pyridostigmine. Equine butyrylcholinesterase, also protected against VX poisoning very effectively.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Poisoning  ISOAche (Rattus norvegicus)5688054; 5688054 RGD 
Poisoning  IDA 5688054 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ache  (acetylcholinesterase)

Genes (Mus musculus)
Ache  (acetylcholinesterase)

Genes (Homo sapiens)
ACHE  (acetylcholinesterase (Yt blood group))


Additional Information