RGD Reference Report - Circulating adiponectin levels in Kawasaki disease. - Rat Genome Database

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Circulating adiponectin levels in Kawasaki disease.

Authors: Takeshita, S  Takabayashi, H  Yoshida, N 
Citation: Takeshita S, etal., Acta Paediatr. 2006 Oct;95(10):1312-4.
RGD ID: 5686751
Pubmed: PMID:16982510   (View Abstract at PubMed)
DOI: DOI:10.1080/08035250600609799   (Journal Full-text)

AIM: To investigate the kinetics of adipocytokine in Kawasaki disease (KD). METHODS: The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 healthy children (HC). RESULTS: Plasma adiponectin levels in patients with acute KD were significantly lower (p < 0.01) than those with convalescent KD, DC and HC. The decreased levels of adiponectin negatively correlated with the increased levels of CRP and IL-6 in acute KD. CONCLUSION: Hypoadiponectinaemia was shown during the acute phase of KD vasculitis. The downregulation of adiponectin secreted from adipose tissue may be closely linked to upregulation of systemic pro-inflammatory markers in acute KD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Kawasaki disease  IEP 5686751protein:decreased expression:plasmaRGD 
Kawasaki disease  ISOADIPOQ (Homo sapiens)5686751; 5686751protein:decreased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information