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Differential cerebro spinal fluid proteome investigation of Leber hereditary optic neuropathy (LHON) and multiple sclerosis.

Authors: D'Aguanno, S  Barassi, A  Lupisella, S  D'eril, GM  Del Boccio, P  Pieragostino, D  Pallotti, F  Carelli, V  Valentino, ML  Liguori, R  Avoni, P  Bernardini, S  Gambi, D  Urbani, A  Federici, G 
Citation: D'Aguanno S, etal., J Neuroimmunol. 2008 Jan;193(1-2):156-60. Epub 2007 Dec 3.
Pubmed: (View Article at PubMed) PMID:18061280
DOI: Full-text: DOI:10.1016/j.jneuroim.2007.10.004

Leber's hereditary optic neuropathy (LHON) is a genetic disease leading to the loss of central vision and optic nerve atrophy. The existence of occasional cases of LHON patients developing a Multiple Sclerosis (MS)-like illness and the hypothesis that mtDNA variants may be involved in MS suggest the possibility of some common molecular mechanisms linking the two diseases. We have pursued a comparative proteomics approach on cerebrospinal fluid (CSF) samples from LHON and MS patients, as well as healthy donors by employing 2-DE gel separations coupled to MALDI-TOF-MS and nLC-MS/MS investigations. 7 protein spots showed significant differential distribution among the three groups. Both CSF of LHON or MS patients are characterized by lower level of transthyretin dimer adduct while a specific up regulation of Apo A-IV was detected in LHON CSF.

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RGD Object Information
RGD ID: 5685659
Created: 2012-01-16
Species: All species
Last Modified: 2012-01-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.