RGD Reference Report - Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy.

General

Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy.
Authors:	Tuncel, N Sener, E Cerit, C Karasu, U Gurer, F Sahinturk, V Baycu, C Ak, D Filiz, Z
Citation:	Tuncel N, etal., Peptides. 2005 May;26(5):827-36.
RGD ID:	5685601
Pubmed:	PMID:15808913 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.peptides.2004.12.019 (Journal Full-text)
In the present study, the effect of systemically administered vasoactive intestinal peptide (VIP) (25 ng/kg i.p.) was investigated on drug-induced rotational behavior, extra-cellular dopamine levels and histology of corpus striatum in a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. After 15 days of 6-OHDA lesion, apomorphine-induced (0.05 mg/kg s.c.) rotational behavior of the animals significantly increased and extra-cellular dopamine levels of corpus striatum were significantly reduced. VIP reversed the rotational deficits but did not alter the decrease in striatal dopamine levels. On the other hand, histological data indicate that VIP significantly reduced neuronal death and demyelination. Electron microscopic appearance of mast cells showed ultra-structural variety between VIP-treated and 6-OHDA lesioned groups. VIP activates mast cells without any evidence of typical exocytosis, and possibly mast cells could participate in neuroprotection. Our results suggest that systemically administered VIP can attenuate the motor response changes, neuronal cell death, and myelin sheet loss characteristically associated with 12 microg 6-OHDA administration into the rat striatum. Brain mast cells seem to participate in neuronal protection. Possibly, protective cues could be produced by brain mast cells.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Parkinsonism		ISO	Vip (Rattus norvegicus)	5685601; 5685601		RGD
Parkinsonism		IMP		5685601		RGD

Objects Annotated

Genes (Rattus norvegicus)

Vip (vasoactive intestinal peptide)

Genes (Mus musculus)

Vip (vasoactive intestinal polypeptide)

Genes (Homo sapiens)

VIP (vasoactive intestinal peptide)

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Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy.