RGD Reference Report - Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis. - Rat Genome Database

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Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis.

Authors: Khan, I  Hussein, SM  Oriowo, MA 
Citation: Khan I, etal., Pharmacology. 2002 Feb;64(2):98-105.
RGD ID: 5684894
Pubmed: PMID:11803250   (View Abstract at PubMed)

Ulcerative colitis is characterized by dysfunctional motility. Our main objective in this investigation was to study the effect of an acetic acid-induced ulcerative colitis on the expression and function of beta(3)-adrenoceptors in the rat colon. Inflammation was induced by administering acetic acid intrarectally into rats. Levels of myeloperoxidase activity and beta(3)-adrenoceptor mRNA were measured in colon samples taken following acetic acid administration. Relaxation responses to beta(3)-adrenoceptor agonists were also studied. Ulcerative colitis was associated with significantly elevated levels of myeloperoxidase activity in the colon segments. Levels of beta(3)-adrenoceptor mRNA as well as the relaxation responses to isoprenaline and BRL 37344 were however not significantly different between inflamed and control tissue. Acetic acid-induced ulcerative colitis in rats was not associated with changes in the expression and/or function of beta(3)-adrenoceptors in the rat colon. Therefore, the dysfunctional motility that is characteristic of ulcerative colitis, is not likely to be due to changes in beta(3)-adrenergic mechanisms in this model.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRB3HumanExperimental Colitis no_associationISOAdrb3 (Rattus norvegicus)mRNA:unaltered expression:colon (rat)RGD 
Adrb3RatExperimental Colitis no_associationIEP mRNA:unaltered expression:colon (rat)RGD 
Adrb3MouseExperimental Colitis no_associationISOAdrb3 (Rattus norvegicus)mRNA:unaltered expression:colon (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb3  (adrenoceptor beta 3)

Genes (Mus musculus)
Adrb3  (adrenergic receptor, beta 3)

Genes (Homo sapiens)
ADRB3  (adrenoceptor beta 3)


Additional Information