RGD Reference Report - Polymorphism of the beta3-adrenergic receptor and lipid profile in patients with rheumatoid arthritis and systemic lupus erythematosus treated with chloroquine. - Rat Genome Database

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Polymorphism of the beta3-adrenergic receptor and lipid profile in patients with rheumatoid arthritis and systemic lupus erythematosus treated with chloroquine.

Authors: Munoz-Valle, JF  Vazquez-Del Mercado, M  Ruiz-Quezada, S  Oregon-Romero, E  Navarro-Hernandez, RE  Ramirez-Barragan, J  Martinez-Bonilla, G  Bernard-Medina, G  Bastidas-Ramirez, BE  Ruiz-Madrigal, B  Panduro, A 
Citation: Munoz-Valle JF, etal., Rheumatol Int. 2003 May;23(3):99-103. Epub 2003 Mar 12.
RGD ID: 5684893
Pubmed: PMID:12739037   (View Abstract at PubMed)
DOI: DOI:10.1007/s00296-002-0266-z   (Journal Full-text)

We investigated the effect of beta 3-adrenergic receptor (beta(3)AR) polymorphism on lipid profiles in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) treated with chloroquine. One hundred sixty-eight subjects were classified into three groups: 61 RA patients, 57 SLE patients, and 50 healthy subjects. All patients fulfilled the 1987 and 1982 classification criteria for RA and SLE, respectively, of the American College of Rheumatology. Demographic data and clinical characteristics of the patients were registered. Fasting lipid profile determination and leukocyte genomic DNA isolation from peripheral blood was performed in all the participants. Screening of the beta(3)-AR gene polymorphic region (exon 1) was done by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Quantitative and qualitative variables were analyzed using analysis of variance (ANOVA) with the LSD and chi(2) tests, respectively. An association between the arg64/arg64 beta(3)-AR genotype and high levels of triglycerides (TG) and very low-density lipoprotein cholesterol (VLDL-c) was found in three RA patients ( P=0.01), two of them taking chloroquine. Arg64/arg64 beta(3)-AR polymorphism may contribute to increased TG and VLDL-c in RA patients, independently of chloroquine treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRB3Humanrheumatoid arthritis  IAGP DNA:missense mutation:cds:p.W64R rs4994 (human)RGD 
Adrb3Ratrheumatoid arthritis  ISOADRB3 (Homo sapiens)DNA:missense mutation:cds:p.W64R rs4994 (human)RGD 
Adrb3Mouserheumatoid arthritis  ISOADRB3 (Homo sapiens)DNA:missense mutation:cds:p.W64R rs4994 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRB3HumanInterphalangeal joint erosions  IAGP DNA:missense mutation:cds:p.W64R (rs4994) RGD 
ADRB3HumanJoint stiffness  IAGP DNA:missense mutation:cds:p.W64R (rs4994) RGD 
ADRB3HumanJoint swelling  IAGP DNA:missense mutation:cds:p.W64R (rs4994) RGD 
ADRB3HumanRheumatoid factor positive  IAGP DNA:missense mutation:cds:p.W64R (rs4994) RGD 
ADRB3HumanSoft tissue swelling of interphalangeal joints  IAGP DNA:missense mutation:cds:p.W64R (rs4994) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Adrb3  (adrenoceptor beta 3)

Genes (Mus musculus)
Adrb3  (adrenergic receptor, beta 3)

Genes (Homo sapiens)
ADRB3  (adrenoceptor beta 3)


Additional Information