RGD Reference Report - BDNF and CGRP interaction: implications in migraine susceptibility. - Rat Genome Database

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BDNF and CGRP interaction: implications in migraine susceptibility.

Authors: Lemos, C  Mendonca, D  Pereira-Monteiro, J  Barros, J  Sequeiros, J  Alonso, I  Sousa, A 
Citation: Lemos C, etal., Cephalalgia. 2010 Nov;30(11):1375-82. Epub 2010 May 10.
RGD ID: 5684020
Pubmed: PMID:20959432   (View Abstract at PubMed)
DOI: DOI:10.1177/0333102410368443   (Journal Full-text)

OBJECTIVES: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene (BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene (CGRP); and a possible interaction between the two. METHODS: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (rs7124442, rs6265, rs11030107, and rs2049046) of BDNF and one tagging SNP-rs1553005-of CGRP were analyzed in 188 cases and 287 controls. A multivariable logistic regression was performed, adjusting for gender. Allelic and haplotypic frequencies were estimated. Interaction was assessed by a stepwise multivariable-logistic regression and confirmed by a multifactor dimensionality reduction analysis. RESULTS: No significant main effects were found; however, a significant interaction was found between BDNF and CGRP, showing an increased risk for the AT-genotype of rs2049046 and the GC-genotype of rs1553005 (odds ratio=1.88, 95% confidence interval: 1.20-2.93) for migraineurs. CONCLUSION: Our data support the hypothesis of an interaction between BDNF and CGRP in migraine susceptibility that should be further explored.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
migraine  IAGP 5684020 RGD 
migraine  ISOCALCA (Homo sapiens)5684020; 5684020 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Calca  (calcitonin-related polypeptide alpha)

Genes (Mus musculus)
Calca  (calcitonin/calcitonin-related polypeptide, alpha)

Genes (Homo sapiens)
CALCA  (calcitonin related polypeptide alpha)


Additional Information