RGD Reference Report - Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation. - Rat Genome Database

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Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.

Authors: Zhou, J  Fu, Y  Tang, XC 
Citation: Zhou J, etal., Neurosci Lett. 2001 Jun 22;306(1-2):53-6.
RGD ID: 5510037
Pubmed: PMID:11403956   (View Abstract at PubMed)

Huperzine A (HupA) and donepezil, two novel selective acetylcholinesterase inhibitors available for Alzheimer's disease, were tested for their ability to alleviate injury from oxygen-glucose deprivation (OGD) in the rat pheochromocytoma line PC12 cells. OGD for 30 min triggered death in more than 50% of cells, along with major changes in morphology and biochemistry including elevated levels of lipid peroxide, superoxide disamutase activity and lactate. Cells pretreated for 2 h with HupA or donepezil showed improved survival and reduced biochemical and morphologic signs of toxicity (statistically significant over the range from 10 microM down to 1.0 and 0.1 microM, respectively). Our results indicated that HupA and donepezil protected PC12 cells against OGD-induced toxicity, most likely by alleviating disturbances of oxidative and energy metabolism.

Objects referenced in this article
Gene ACHE acetylcholinesterase (Yt blood group) Homo sapiens
Gene Ache acetylcholinesterase Mus musculus
Gene Ache acetylcholinesterase Rattus norvegicus

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