RGD Reference Report - An association between Gc (vitamin D-binding protein) alleles and susceptibility to rheumatic fever. - Rat Genome Database

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An association between Gc (vitamin D-binding protein) alleles and susceptibility to rheumatic fever.

Authors: Bahr, GM  Eales, LJ  Nye, KE  Majeed, HA  Yousof, AM  Behbehani, K  Rook, GA 
Citation: Bahr GM, etal., Immunology. 1989 May;67(1):126-8.
RGD ID: 5509933
Pubmed: PMID:2737695   (View Abstract at PubMed)
PMCID: PMC1385300   (View Article at PubMed Central)

Rheumatic fever is associated with exaggerated activity of B cells with massive production of antibody to the Group A streptococcus. Gc (vitamin D-binding protein) is constitutively expressed on B-cell membranes in association with membrane immunoglobulin, and could be involved in cell activation. We therefore looked for associations between the three major Gc alleles and susceptibility to rheumatic fever in a homogeneous Arab population. Patients with tuberculosis or rheumatoid arthritis and control donors, were studied in parallel. Allele frequencies in the controls, rheumatoid and tuberculosis patients were identical to those found in a previous study of normal Arab donors. However, there was a striking association between Gc2 and rheumatic fever. This allele was twice as common in these patients as in controls (p = 0.0024), and was present in 56.4% of all rheumatic fever patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rheumatic fever  IAGP 5509933 RGD 
rheumatic fever  ISORDG:7369025509933; 5509933 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gc  (GC, vitamin D binding protein)

Genes (Mus musculus)
Gc  (vitamin D binding protein)

Genes (Homo sapiens)
GC  (GC vitamin D binding protein)


Additional Information