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Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain.

Authors: Machado-Vieira, R  Schmidt, AP  Avila, TT  Kapczinski, F  Soares, JC  Souza, DO  Portela, LV 
Citation: Machado-Vieira R, etal., Life Sci. 2004 Dec 31;76(7):805-11.
Pubmed: (View Article at PubMed) PMID:15581912
DOI: Full-text: DOI:10.1016/j.lfs.2004.07.021

Bipolar disorder is a chronic and severe mental disorder. Recently, new animal models have emerged to further investigate underlying mechanisms of bipolar disorder such as ouabain-induced hyperactivity in rats. In this study, we investigated the cerebrospinal fluid levels of S100B protein as a putative marker of astrocytic activity in bipolar mania induced by intracerebroventricular administration of ouabain in rats. Ouabain induced a two-fold increase in crossing responses in the open field test and increased 30% the cerebrospinal fluid concentration of S100B, as compared to vehicle group. Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania.


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RGD Object Information
RGD ID: 5508853
Created: 2011-10-25
Species: All species
Last Modified: 2011-10-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.