RGD Reference Report - Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. - Rat Genome Database

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Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model.

Authors: Geddes, K  Rubino, S  Streutker, C  Cho, JH  Magalhaes, JG  Le Bourhis, L  Selvanantham, T  Girardin, SE  Philpott, DJ 
Citation: Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4.
RGD ID: 5508755
Pubmed: PMID:20921147   (View Abstract at PubMed)
PMCID: PMC2981303   (View Article at PubMed Central)
DOI: DOI:10.1128/IAI.00759-10   (Journal Full-text)

The pattern recognition molecules Nod1 and Nod2 play important roles in intestinal homeostasis; however, how these proteins impact on the development of inflammation during bacterial colitis has not been examined. In the streptomycin-treated mouse model of Salmonella colitis, we found that mice deficient for both Nod1 and Nod2 had attenuated inflammatory pathology, reduced levels of inflammatory cytokines, and increased colonization of the mucosal tissue. Nod1 and Nod2 from both hematopoietic and nonhematopoietic sources contributed to the pathology, and all phenotypes were recapitulated in mice deficient for the signaling adaptor protein Rip2. However, the influence of Rip2 was strictly dependent on infection conditions that favored expression of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (TTSS), as Rip2 was dispensable for inflammation when mice were infected with bacteria grown under conditions that promoted expression of the SPI-1 TTSS. Thus, Nod1 and Nod2 can modulate inflammation and mediate efficient clearance of bacteria from the mucosal tissue during Salmonella colitis, but their role is dependent on the expression of the SPI-2 TTSS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NOD1Humancolitis  ISONod1 (Mus musculus) RGD 
NOD2Humancolitis  ISONod2 (Mus musculus) RGD 
Nod1Mousecolitis  IMP  RGD 
Nod1Ratcolitis  ISONod1 (Mus musculus) RGD 
Nod2Ratcolitis  ISONod2 (Mus musculus) RGD 
Nod2Mousecolitis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nod1  (nucleotide-binding oligomerization domain containing 1)
Nod2  (nucleotide-binding oligomerization domain containing 2)

Genes (Mus musculus)
Nod1  (nucleotide-binding oligomerization domain containing 1)
Nod2  (nucleotide-binding oligomerization domain containing 2)

Genes (Homo sapiens)
NOD1  (nucleotide binding oligomerization domain containing 1)
NOD2  (nucleotide binding oligomerization domain containing 2)


Additional Information