RGD Reference Report - FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis. - Rat Genome Database

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FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis.

Authors: Andren, M  Xiang, Z  Nilsson, G  Kleinau, S 
Citation: Andren M, etal., Scand J Immunol. 2006 Apr;63(4):282-9.
RGD ID: 5508457
Pubmed: PMID:16623928   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-3083.2006.01743.x   (Journal Full-text)

IgG-binding Fc receptors, and in particular FcgammaRIII, are crucial for induction of collagen-induced arthritis (CIA), as FcgammaRIII-deficient mice are highly protected to arthritis. However, which of the FcgammaRIII-expressing cells that is responsible for induction of arthritis is not known. In this study, we have addressed this question by purifying different FcgammaRIII(+) cell populations, transferred them to FcgammaRIII-deficient mice and studied if the recipient mice can develop arthritis. The cell populations were isolated from spleen, bone marrow and the peritoneal cavity. Our results show that FcgammaRIII(+) CD11b(+) peritoneal macrophages can render FcgammaRIII-deficient mice susceptible to CIA. In contrast, FcgammaRIII(-) peritoneal macrophages or FcgammaRIII(+) spleenocytes, bone marrow cells, mast cells or monocytes could not mediate this effect. To further evaluate the contribution of the FcgammaRIII(+) macrophages in arthritis, we investigated the cytokine profile in these cells during CIA. The arthritic macrophages exhibited significantly higher mRNA levels of TNFalpha and IL-12p35 compared with macrophages from normal mice. We conclude that FcgammaRIII-expressing macrophages, producing pro-inflammatory cytokine and T helper type 1 differentiating factor, are the major effector cells in the induction of CIA.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanExperimental Arthritis  ISOFcgr3 (Mus musculus) RGD 
Fcgr2aRatExperimental Arthritis  ISOFcgr3 (Mus musculus) RGD 
Fcgr3MouseExperimental Arthritis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information