RGD Reference Report - Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients. - Rat Genome Database

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Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients.

Authors: Lehmann, C  Lafferty, M  Garzino-Demo, A  Jung, N  Hartmann, P  Fatkenheuer, G  Wolf, JS  Van Lunzen, J  Romerio, F 
Citation: Lehmann C, etal., PLoS One. 2010 Jun 14;5(6):e11110.
RGD ID: 5490533
Pubmed: PMID:20559432   (View Abstract at PubMed)
PMCID: PMC2885422   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0011110   (Journal Full-text)

Circulating plasmacytoid dendritic cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha (IFNalpha), which is associated with HIV-1 disease progression. Here we show an accumulation of pDC in lymph nodes (LN) of treatment-naive HIV-1 patients. This phenomenon was associated with elevated expression of the LN homing marker, CCR7, on pDC in peripheral blood of HIV-1 patients, which conferred increased migratory capacity in response to CCR7 ligands in ex vivo functional assays. LN-homed pDC of HIV-1 patients presented higher CD40 and lower BDCA2 levels, but unchanged CD83 and CD86 expression. In addition, these cells expressed markedly higher amounts of IFNalpha compared to uninfected individuals, and were undergoing faster rates of cell death. These results demonstrate for the first time that in asymptomatic, untreated HIV-1 patients circulating pDC up-regulate CCR7 expression, accumulate in lymph nodes, and express high amounts of IFNalpha before undergoing cell death. Since IFNalpha inhibits cell proliferation and modulates immune responses, chronically high levels of this cytokine in LN of HIV-1 patients may impair differentiation and immune function of bystander CD4(+) T cells, thus playing into the mechanisms of AIDS immunopathogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
human immunodeficiency virus infectious disease  IEP 5490533protein:increased expression:plasmacytoid dendritic cell RGD 
human immunodeficiency virus infectious disease  ISOCD40 (Homo sapiens)5490533; 5490533protein:increased expression:plasmacytoid dendritic cell RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)

Genes (Mus musculus)
Cd40  (CD40 antigen)

Genes (Homo sapiens)
CD40  (CD40 molecule)


Additional Information