RGD Reference Report - The Fcgamma receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia. - Rat Genome Database

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The Fcgamma receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia.

Authors: Sole-Violan, J  Garcia-Laorden, MI  Marcos-Ramos, JA  De Castro, FR  Rajas, O  Borderias, L  Briones, ML  Herrera-Ramos, E  Blanquer, J  Aspa, J  Florido, Y  Garcia-Bello, MA  Ferrer-Aguero, JM  Sologuren, I  Rodriguez-Gallego, C 
Citation: Sole-Violan J, etal., Crit Care Med. 2011 Jun;39(6):1388-93.
RGD ID: 5147986
Pubmed: PMID:21317643   (View Abstract at PubMed)
DOI: DOI:10.1097/CCM.0b013e31820eda74   (Journal Full-text)

OBJECTIVE: To assess the potential association of the functional polymorphism rs1801274 in the receptor IIa for the Fc portion of immunoglobin G (FcgammaRIIa) gene (FCGR2A-H131R) with the susceptibility to and the severity of community-acquired pneumonia (CAP). DESIGN: Multicenter prospective and observational study. SETTING: Four university hospitals in Spain. PATIENTS: FCGR2A-H131R polymorphism was determined in 1,262 patients with CAP and in 1,224 in the subject control group. MEASUREMENTS AND MAIN RESULTS: Severe sepsis was recorded in 366 patients. No significant differences in genotype or allele frequencies were seen among patients with CAP or pneumococcal CAP (PCAP) and controls. Patients with bacteremic PCAP (B-PCAP) had significantly higher frequencies of FCGR2A-H/H131 genotypes than those with nonbacteremic PCAP (p = .00016, odds ratio = 2.9, 95% confidence interval 1.58-5.3). The differences remained significant when adjusting for pneumonia severity index, hospital of origin, and intensive care unit admission (p = .0012, odds ratio = 2.83, 95% confidence interval 1.51-5.32). B-PCAP was associated with a significantly higher severity of the disease, evaluated as sepsis severity (p = .000007, odds ratio = 4.40, 95% confidence interval 2.31-8.39), multiorgan dysfunction syndrome (0.00048, odds ratio = 3.29, 95% confidence interval 1.69-6.41), intensive care unit admission, acute renal failure, and acute respiratory distress syndrome. CONCLUSIONS: Our results do not support a role of FCGR2A-H131R polymorphism in susceptibility to CAP or PCAP. However, we provide the insight that homozygosity for FCGR2A-H131 predisposes B-PCAP, which was associated with higher severity in our study.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanBacteremia  IAGP associated with Pneumonia and DNA:SNP: :p.H131R (rs1801274) (human)RGD 
Fcgr2aRatBacteremia  ISOFCGR2A (Homo sapiens)associated with Pneumonia and DNA:SNP: :p.H131R (rs1801274) (human)RGD 
Fcgr3MouseBacteremia  ISOFCGR2A (Homo sapiens)associated with Pneumonia and DNA:SNP: :p.H131R (rs1801274) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information