RGD Reference Report - No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS. - Rat Genome Database

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No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS.

Authors: Breij, EC  Van der Pol, WL  Van Winsen, L  Jansen, MD  Dijkstra, CD  Van De Winkel, JG  Uitdehaag, BM 
Citation: Breij EC, etal., J Neuroimmunol. 2003 Jul;140(1-2):210-5.
RGD ID: 5147977
Pubmed: PMID:12864991   (View Abstract at PubMed)

Anti-myelin IgGs occur in the cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients, and can induce inflammatory effector functions in leukocytes by crosslinking IgG receptors (FcgammaR). The efficiency of FcgammaR-mediated inflammatory processes is affected by functional polymorphisms of three Fcgamma receptors (FcgammaRIIa, FcgammaRIIIa, FcgammaRIIIb). The relevance of FcgammaR polymorphisms in MS was evaluated by studying the distribution of FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb genotypes in 432 MS patients and 515 healthy controls. No significant differences were found between MS patients and controls, or between subgroups of patients. We conclude that Fcgamma receptor polymorphisms influence neither susceptibility nor clinical disease course of MS.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanmultiple sclerosis no_associationIAGP DNA:polymorphism: :p.H131R (human)RGD 
Fcgr2aRatmultiple sclerosis no_associationISOFCGR2A (Homo sapiens)DNA:polymorphism: :p.H131R (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information