RGD Reference Report - Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the Fc gamma receptor IIA. - Rat Genome Database

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Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the Fc gamma receptor IIA.

Authors: Kim, YS  Yoo, JH  Lee, BC 
Citation: Kim YS, etal., Blood Coagul Fibrinolysis. 2009 Jul;20(5):353-7.
RGD ID: 5147924
Pubmed: PMID:19357503   (View Abstract at PubMed)
DOI: DOI:10.1097/MBC.0b013e32832a86fe   (Journal Full-text)

Fc gamma receptor IIA could influence atherogenic processes through the production of superoxide anions, cytokines, and proteolytic enzymes as well as by oxidation of lipoproteins and enhancement of foam cell formation. In this study, we performed an interaction analysis between FCGR2A polymorphisms and ischemic stroke using direct DNA sequencing after the selection of Fc gamma receptor IIA gene based on genome-wide association study. Four of the FCGR2A polymorphisms, rs7511868 [odds ratio (OR) = 3.21; P = 0.027], rs6427595 (OR = 3.12; P = 0.008), rs7512140 (OR = 5.71; P = 0.002), and rs6696854 (OR = 3.65; P = 0.004) were significantly associated with ischemic stroke. These four polymorphisms still showed significant association after stratification analysis using the Mantel-Haenszel method. In the multivariate logistic regression, the adjusted OR estimates for rs6427595, rs7512140, and rs6696854 were 3.04 (P = 0.016), 4.84 (P = 0.015), and 3.80 (P = 0.006), respectively. The diplotype consisting of two homozygous haplotypes (H2 = AAAC) was significantly associated with ischemic stroke (OR = 17.39; P < 0.001). These results suggest that FCGR2A polymorphisms may be associated with a genetic susceptibility to ischemic stroke in a Korean population.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanStroke susceptibilityIAGP DNA:SNPs:enhancers:multipleRGD 
Fcgr2aRatStroke susceptibilityISOFCGR2A (Homo sapiens)DNA:SNPs:enhancers:multipleRGD 
Fcgr3MouseStroke susceptibilityISOFCGR2A (Homo sapiens)DNA:SNPs:enhancers:multipleRGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanIschemic stroke susceptibilityIAGP DNA:SNPs:enhancers:multipleRGD 
Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information