RGD Reference Report - Susceptibility for ischemic stroke in four constitution medicine is associated with polymorphisms of FCGR2A and IL1RN genes. - Rat Genome Database

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Susceptibility for ischemic stroke in four constitution medicine is associated with polymorphisms of FCGR2A and IL1RN genes.

Authors: Lee, BC  Lee, H  Park, HK  Yang, JS  Chung, JH 
Citation: Lee BC, etal., Neurol Res. 2010 Feb;32 Suppl 1:43-7.
RGD ID: 5147920
Pubmed: PMID:20034444   (View Abstract at PubMed)
DOI: DOI:10.1179/016164109X12537002793922   (Journal Full-text)

OBJECTIVES: To determine the association between Four Constitutional classification and Fc fragment of IgG, low affinity of IIa, receptor (FCGR2A) and interleukin 1 receptor antagonist (IL1RN) in Korean ischemic stroke patients. METHODS: We classified the Four Constitutional types in ischemic stroke patients (n=162) and healthy control subjects (n=135), and genotyped FCGR2A and IL1RN polymorphisms using direct DNA sequencing and polymerase chain reaction (PCR) methods. RESULTS: In the IL1RN polymorphisms, the IL1RN*1/IL1RN*2 genotype (OR=5.80, p=0.0142), and in the FCGR2A polymorphisms, the rs7535475 (OR=0.58, p=0.0218) and rs7512140 (OR=0.09, p=0.0335), were significantly associated with ischemic stroke. The prevalence of IL1RN*1/IL1RN*2 genotype of IL1RN and rs7535475 of FCGR2A in greater Yin person ischemic stroke patients were different from greater Yin person healthy controls (OR=18.97, p=0.0063; OR=0.38, p=0.0045). DISCUSSION: These results suggest that IL1RN*1/IL1RN*2 genotype in greater Yin person might be associated with increased risk of ischemic stroke, and rs7535475 of FCGR2A might be associated with decreased risk of ischemic stroke. Furthermore, this relationship could provide the basis for a new approach in investigating the etiology of ischemic stroke.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanStroke susceptibilityIAGP DNA:SNPs:enhancers: (rs7512140 and rs7535475) (human)RGD 
Fcgr2aRatStroke susceptibilityISOFCGR2A (Homo sapiens)DNA:SNPs:enhancers: (rs7512140 and rs7535475) (human)RGD 
Fcgr3MouseStroke susceptibilityISOFCGR2A (Homo sapiens)DNA:SNPs:enhancers: (rs7512140 and rs7535475) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanIschemic stroke susceptibilityIAGP DNA:SNPs:enhancers: (rs7512140 and rs7535475)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)


Additional Information