RGD Reference Report - Lack of association between CYP1A1 polymorphism and Parkinson's disease in a Chinese population. - Rat Genome Database

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Lack of association between CYP1A1 polymorphism and Parkinson's disease in a Chinese population.

Authors: Chan, DK  Mellick, GD  Buchanan, DD  Hung, WT  Ng, PW  Woo, J  Kay, R 
Citation: Chan DK, etal., J Neural Transm. 2002;109(1):35-9.
RGD ID: 5147678
Pubmed: PMID:11793160   (View Abstract at PubMed)
DOI: DOI:10.1007/s007020200002   (Journal Full-text)

Apart from very few families who have a direct cause from genetic mutation, causes of most Parkinson's disease (PD) remain unclear. Many allelic association studies on polymorphism of different candidate genes have been studied. Although these association studies do not imply a causal relationship, it does warrant further studies to elucidate the pathophysiologic significance. CYP1A1 polymorphisms have been reported to be associated with PD in a Japanese population sample. Since CYP1A1 transforms aromatic hydrocarbons into products that may be neurotoxic and perhaps lead to PD, we therefore undertook a study to look at the possible association of CYP1A1 polymorphism and PD in a Chinese population. Contrary to the Japanese result, we did not find any statistically significant difference between the PD group and the control group in our study with a bigger sample size.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease no_associationIAGP 5147678DNA:missense mutation:cds:p.I462V (human)RGD 
Parkinson's disease no_associationISOCYP1A1 (Homo sapiens)5147678; 5147678DNA:missense mutation:cds:p.I462V (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinsonism  IAGP 5147678DNA:missense mutation:cds:p.I462VRGD 
Objects Annotated

Genes (Rattus norvegicus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)

Genes (Mus musculus)
Cyp1a1  (cytochrome P450, family 1, subfamily a, polypeptide 1)

Genes (Homo sapiens)
CYP1A1  (cytochrome P450 family 1 subfamily A member 1)


Additional Information