RGD Reference Report - Generic human leukocyte antigen class II (DRB1 and DQB1) alleles in patients with paracoccidioidomycosis. - Rat Genome Database

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Generic human leukocyte antigen class II (DRB1 and DQB1) alleles in patients with paracoccidioidomycosis.

Authors: Sadahiro, A  Roque, AC  Shikanai-Yasuda, MA 
Citation: Sadahiro A, etal., Med Mycol. 2007 Feb;45(1):35-40.
RGD ID: 5147631
Pubmed: PMID:17325942   (View Abstract at PubMed)
DOI: DOI:10.1080/13693780600999132   (Journal Full-text)

Human leukocyte antigen (HLA) class II alleles are involved in antigen processing and in the presentation of antigens to T lymphocytes. Few studies have investigated HLA genes in paracoccidioidomycosis. In the present investigation, we analyzed the distribution of the HLA class II alleles DRB1 and DQB1 in 45 healthy volunteers and in 80 patients with paracoccidioidomycosis. The patients presented with various clinical forms of the disease, and allele distribution was evaluated individually in each presentation type. In patients with the unifocal chronic form of the disease, a mild clinical presentation in which lesions are restricted or localized, the HLA allele most commonly seen was DRB1*11 (p<0.039). This suggests that the participation of HLA antigens may influence the outcome of the host-parasite interaction in paracoccidioidomycosis, regulating the immune response to Paracoccidioides brasiliensis antigens.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
paracoccidioidomycosis severityISOHLA-DRB1 (Homo sapiens)5147631; 5147631DNA:polymorphism and haplotype:cds:HLA-DRB1*11 (human)RGD 
paracoccidioidomycosis severityIAGP 5147631DNA:polymorphism and haplotype:cds:HLA-DRB1*11 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information