RGD Reference Report - Heat-shock protein-70 genes and response to antidepressants in major depression. - Rat Genome Database

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Heat-shock protein-70 genes and response to antidepressants in major depression.

Authors: Pae, Chi-Un  Mandelli, Laura  Serretti, Alessandro  Patkar, Ashwin A  Kim, Jung-Jin  Lee, Chang-Uk  Lee, Soo-Jung  Lee, Chul  De Ronchi, Diana  Paik, In-Ho 
Citation: Pae CU, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. Epub 2007 Feb 27.
RGD ID: 5147598
Pubmed: PMID:17428599   (View Abstract at PubMed)
DOI: DOI:10.1016/j.pnpbp.2007.02.011   (Journal Full-text)

In the search of predictors of antidepressant efficacy, much interest has recently focused on pro-inflammatory proteins, as they were found to be elevated during major depressives states and decreased by antidepressant drugs. In the present paper we investigated the role of the genes coding for heat-shock-70 family proteins, recently hypothesized to be activated by antidepressants and thus mediate the reduction of pro-inflammatory cytosines. One hundred and forty two hospitalised patients, affected by major depression and treated with antidepressants drugs for a major depressive episode were evaluated for depressive severity at the baseline and at the discharge and genotyped for five SNPs within the genes HSPA1L, HSPA1A and HSPA1B. Markers were not individually associated with symptom severity after treatment. Instead, we found a three markers haplotype, including SNPs within HSPA1L and HSPA1A, associated with a poorer response to antidepressant treatment (p=0.005). Single markers as well as haplotypes were not associated with other clinical features. In conclusion, genetic variants within the genes coding for HSP-70 family proteins may affect the action of antidepressants and thus their therapeutic efficacy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HSPA1AHumanmajor depressive disorder  IAGP DNA:SNP: :rs1043618 (human)RGD 
HSPA1LHumanmajor depressive disorder  IAGP DNA:SNPs: :rs2075799 and rs2227956 (human)RGD 
Hspa1aMousemajor depressive disorder  ISOHSPA1A (Homo sapiens)DNA:SNP: :rs1043618 (human)RGD 
Hspa1aRatmajor depressive disorder  ISOHSPA1A (Homo sapiens)DNA:SNP: :rs1043618 (human)RGD 
Hspa1lMousemajor depressive disorder  ISOHSPA1L (Homo sapiens)DNA:SNPs: :rs2075799 and rs2227956 (human)RGD 
Hspa1lRatmajor depressive disorder  ISOHSPA1L (Homo sapiens)DNA:SNPs: :rs2075799 and rs2227956 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspa1a  (heat shock protein family A (Hsp70) member 1A)
Hspa1l  (heat shock protein family A (Hsp70) member 1 like)

Genes (Mus musculus)
Hspa1a  (heat shock protein 1A)
Hspa1l  (heat shock protein 1-like)

Genes (Homo sapiens)
HSPA1A  (heat shock protein family A (Hsp70) member 1A)
HSPA1L  (heat shock protein family A (Hsp70) member 1 like)


Additional Information