RGD Reference Report - Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue. - Rat Genome Database

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Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue.

Authors: Bremer, AA  Tansky, MF  Wu, M  Boyd, ND  Leeman, SE 
Citation: Bremer AA, etal., Eur J Pharmacol. 2001 Jul 6;423(2-3):143-7.
RGD ID: 5147474
Pubmed: (View Article at PubMed) PMID:11448478

Neurokinin A (NKA) is a tachykinin peptide that binds with high affinity to the tachykinin NK(2) receptor. Recent homologous binding studies, however, have shown that neurokinin A is also a high-affinity ligand for the tachykinin NK(1) receptor. In this report, we demonstrate that a photoreactive neurokinin A analogue specifically labels the NK(1) receptor in rat submandibular gland membranes and show via bioassay that neurokinin A is a potent stimulator of salivary secretion. Through the use of specific non-peptide antagonists in both photolabeling and functional assays, we unequivocally demonstrate that neurokinin A can specifically interact with the NK(1) receptor in vivo and elicit NK(1) receptor-mediated physiological responses.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Tac1  (tachykinin, precursor 1)
Tacr1  (tachykinin receptor 1)


Additional Information