RGD Reference Report - Presence of Activated Airway T Lymphocytes in Human Puumala Hantavirus Disease. - Rat Genome Database

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Presence of Activated Airway T Lymphocytes in Human Puumala Hantavirus Disease.

Authors: Rasmuson, J  Pourazar, J  Linderholm, M  Sandstrom, T  Blomberg, A  Ahlm, C 
Citation: Rasmuson J, etal., Chest. 2011 Mar 24.
RGD ID: 5147436
Pubmed: (View Article at PubMed) PMID:21436245
DOI: Full-text: DOI:10.1378/chest.10-2791

Abstract BACKGROUND: Hantaviruses cause two clinical syndromes; hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The clinical spectrum in HFRS also often involves respiratory symptoms. As information of the pulmonary pathogenesis in HFRS is limited, we aimed to further study the local airway immune response in the lower airways. METHODS: In 15 hospitalized HFRS patients, bronchoscopy was performed with sampling of endobronchial mucosal biopsies and bronchoalveolar lavage (BAL) fluid. Biopsies were stained for leukocytes, lymphocyte subsets and vascular endothelial adhesion molecules. BAL fluid and blood lymphocyte subsets were determined using flow cytometry. Fourteen healthy volunteers acted as control group. RESULTS: Compared to controls, endobronchial mucosal biopsies from HFRS patients revealed increased numbers of CD8(+) T cells in both epithelium and submucosa (p

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il2ra  (interleukin 2 receptor subunit alpha)

Genes (Mus musculus)
Il2ra  (interleukin 2 receptor, alpha chain)

Genes (Homo sapiens)
IL2RA  (interleukin 2 receptor subunit alpha)

Additional Information