Effect of acidosis and uninephrectomy on isozymes of adenylosuccinate synthetase in rat kidney.
Tornheim, K Lowenstein, LM
||Tornheim K and Lowenstein LM, Biochim Biophys Acta. 1983 May 4;757(1):137-9.
||(View Article at PubMed) PMID:6838904
Normal rat kidney contains primarily the L isozyme of adenylosuccinate synthetase. The increase in total adenylosuccinate synthetase activity that occurs in response to NH4Cl-feeding or a low potassium diet is mainly due to increase in the L isozyme, rather than to an increase in the M isozyme. 1 day after uninephrectomy there is little change in total adenylosuccinate synthetase activity or isozyme distribution in the remaining kidney. These results do not support extension to kidney of the theory proposed for liver that the L isozyme is involved in purine biosynthesis while the M isozyme is involved in ammonia production from amino acids via the purine nucleotide cycle.