RGD Reference Report - Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. - Rat Genome Database

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Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma.

Authors: Maurizi, M  Almadori, G  Ferrandina, G  Distefano, M  Romanini, ME  Cadoni, G  Benedetti-Panici, P  Paludetti, G  Scambia, G  Mancuso, S 
Citation: Maurizi M, etal., Br J Cancer. 1996 Oct;74(8):1253-7.
RGD ID: 5131485
Pubmed: PMID:8883413   (View Abstract at PubMed)
PMCID: PMC2075924   (View Article at PubMed Central)

Epidermal growth factor receptor (EGFR) content was determined by a radioligand receptor assay in 140 primary laryngeal squamous cell carcinomas (median value of 8.4 fmol mg-1 protein, range 0-169.9 fmol mg-1 protein). Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels are directly associated with the risk of death (chi 2 = 14.56, P-value = 0.0001) and relapse (chi 2 = 7.77, P-value = 0.0053). A significant relationship between EGFR status and survival was observed at the different arbitrary cut-off values chosen (8, 16 and 20 fmol mg-1 protein). The cut-off value of 20 fmol mg-1 protein was the best prognostic discriminator. In fact, the 5 year survival was 81% for patients with EGFR- tumours compared with 25% for patients with EGFR+ tumours (P < 0.0001). The 5 year relapse-free survival was 77% for patients with EGFR- tumours compared with 24% for patients with EGFR+ tumours (P < 0.010). When clinicopathological parameters and EGFR status were examined in the multivariate analysis, T classification and EGFR status retained an independent prognostic value. In this study we demonstrated that high EGFR levels single out patients with poor prognosis in laryngeal cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Laryngeal Neoplasms severityIEP 5131485protein:increased expression:tumor (human)RGD 
Laryngeal Neoplasms severityISOEGFR (Homo sapiens)5131485; 5131485protein:increased expression:tumor (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)


Additional Information