RGD Reference Report - GM-CSF in the Lung Protects Against Lethal Influenza Infection. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GM-CSF in the Lung Protects Against Lethal Influenza Infection.

Authors: Huang, FF  Barnes, PF  Feng, Y  Donis, R  Chroneos, ZC  Idell, S  Allen, T  Perez, DR  Whitsett, JA  Dunussi-Joannopoulos, K  Shams, H 
Citation: Huang FF, etal., Am J Respir Crit Care Med. 2011 Apr 7.
RGD ID: 5131470
Pubmed: PMID:21474645   (View Abstract at PubMed)
PMCID: PMC6938174   (View Article at PubMed Central)
DOI: DOI:10.1164/rccm.201012-2036OC   (Journal Full-text)

RATIONALE: Alveolar macrophages contribute to host defenses against influenza in animal models. Enhancing alveolar macrophage function may contribute to protection against influenza OBJECTIVE: To determine if increased expression of granulocyte-macrophage colony stimulating factor in the lung increases resistance to influenza METHODS: Wild-type mice and transgenic mice that expressed granulocyte macrophage-colony stimulating factor in the lung were infected with influenza virus, and lung pathology, weight loss and mortality were measured. We also administered granulocyte-macrophage colony stimulating factor to the lungs of wild-type mice that were infected with influenza virus. MEASUREMENTS AND MAIN RESULTS: Wild-type mice all died after infection with different strains of influenza virus, but all transgenic mice expressing granulocyte-macrophage colony stimulating factor in the lungs survived. The latter also had greatly reduced weight loss and lung injury, and showed histologic evidence of a rapid host inflammatory response that controlled infection. The resistance of transgenic mice to influenza was abrogated by elimination of alveolar phagocytes, but not by depletion of T-cells, B-cells or neutrophils. Transgenic mice had far more alveolar macrophages than wild-type mice, and they were more resistant to influenza-induced apoptosis. Delivery of intranasal granulocyte macrophage-colony stimulating factor to wild-type mice also conferred resistance to influenza. CONCLUSIONS: Granulocyte-macrophage colony stimulating factor confers resistance to influenza by enhancing innate immune mechanisms that depend on alveolar macrophages. Pulmonary delivery of this cytokine has the potential to reduce the morbidity and mortality due to influenza virus.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Human Influenza  ISOCsf2 (Mus musculus)5131470; 5131470 RGD 
Human Influenza  IMP 5131470 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf2  (colony stimulating factor 2)

Genes (Mus musculus)
Csf2  (colony stimulating factor 2 (granulocyte-macrophage))

Genes (Homo sapiens)
CSF2  (colony stimulating factor 2)


Additional Information