RGD Reference Report - A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature. - Rat Genome Database

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A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature.

Authors: Takaguri, A  Kimura, K  Hinoki, A  Bourne, AM  Autieri, MV  Eguchi, S 
Citation: Takaguri A, etal., Hypertension. 2011 Apr;57(4):841-5. Epub 2011 Feb 28.
RGD ID: 5131466
Pubmed: PMID:21357274   (View Abstract at PubMed)
PMCID: PMC3311130   (View Article at PubMed Central)
DOI: DOI:10.1161/HYPERTENSIONAHA.110.166892   (Journal Full-text)

The requirement of a metalloprotease, a disintegrin and metalloprotease 17 (ADAM17) for the growth of cultured vascular smooth muscle cells has been demonstrated in vitro. However, whether this metalloprotease is responsible for vascular remodeling in vivo remains unanswered. Rat carotid arteries were analyzed 2 weeks after a balloon angioplasty. The neointimal cells were strongly positive for ADAM17 immunostaining. Marked inhibition of intimal hyperplasia was observed in a dominant-negative ADAM17 adenovirus-treated carotid artery. Proliferating cell nuclear antigen-positive cells and phospho-epidermal growth factor receptor-positive cells in the neointima were reduced by dominant-negative ADAM17 as well. In contrast, the neointima formation, proliferating cell nuclear antigen-positive cells, and phospho-epidermal growth factor receptor-positive cells were markedly enhanced by wild-type ADAM17 adenovirus. In conclusion, ADAM17 activation is involved in epidermal growth factor receptor activation and subsequent neointimal hyperplasia after vascular injury. ADAM17 could be a novel therapeutic target for pathophysiological vascular remodeling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hyperplasia  ISOEgfr (Rattus norvegicus)5131466; 5131466protein:increased expression:carotid artery (rat)RGD 
Hyperplasia  IEP 5131466protein:increased expression:carotid artery (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)


Additional Information