RGD Reference Report - Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis? - Rat Genome Database

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Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?

Authors: Bogefors, J  Rydberg, C  Uddman, R  Fransson, M  Mansson, A  Benson, M  Adner, M  Cardell, LO 
Citation: Bogefors J, etal., Allergy. 2010 Oct;65(10):1222-6. Epub 2010 Apr 7.
RGD ID: 5131446
Pubmed: PMID:20384614   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1398-9995.2009.02315.x   (Journal Full-text)

BACKGROUND: Recently, a new set of pattern-recognition receptors, the nucleotide-binding oligomerization domain (Nod)-like receptors (NLRs), have emerged. Their activation, either by allergens or microbes, triggers an inflammatory response. The knowledge about NLRs in human airways is limited. AIM OF THE STUDY: To investigate presence of NLRs in the human nose of healthy individuals and patients with intermittent allergic rhinitis outside and during pollen season. METHODS: The expression of Nod1, Nod2, and Nalp3 in nasal biopsies was determined with real-time RT-PCR and immunohistochemistry. Cultured primary human nasal epithelial cells (HNECs) were analyzed using real-time RT-PCR and flow cytometry to further verify the presence of NLRs in the epithelium. RESULTS: Immunohistochemical analysis revealed presence of Nod1, Nod2, and Nalp3 in the nasal epithelium. This was corroborated in cultured HNECs. Patients suffering from symptomatic allergic rhinitis exhibited lower Nod1 and Nalp3 mRNA levels than both controls and patients during pollen season. Nod2 expression was found in all specimens tested, but no differences were seen between the three groups. CONCLUSION: Nod1, Nod2, and Nalp3 receptors were found to be present in the human nose. The expression of Nod1 and Nalp3 were down-regulated during pollen season among patients with allergic rhinitis. This opens up for new insights and novel therapeutic strategies in inflammatory airway disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NOD1Humanrhinitis  IEP mRNA:decreased expression:noseRGD 
Nod1Mouserhinitis  ISONOD1 (Homo sapiens)mRNA:decreased expression:noseRGD 
Nod1Ratrhinitis  ISONOD1 (Homo sapiens)mRNA:decreased expression:noseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nod1  (nucleotide-binding oligomerization domain containing 1)

Genes (Mus musculus)
Nod1  (nucleotide-binding oligomerization domain containing 1)

Genes (Homo sapiens)
NOD1  (nucleotide binding oligomerization domain containing 1)

Additional Information