RGD Reference Report - KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn. - Rat Genome Database

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KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn.

Authors: Ogihara, T  Hirano, K  Morinobu, T  Ogawa, S  Hiroi, M  Ban, R  Ogihara, H  Tamai, H 
Citation: Ogihara T, etal., J Pediatr. 2000 Aug;137(2):280-2.
RGD ID: 5131182
Pubmed: PMID:10931429   (View Abstract at PubMed)
DOI: DOI:10.1067/mpd.2000.107109   (Journal Full-text)

KL-6 is a mucinous glycoprotein that is preferentially expressed by alveolar type 2 cells. Plasma KL-6 was higher in infants with chronic lung disease (n = 12) than in infants without chronic lung disease (n = 14) on day 0-1, 10, and 30 (P =.04). KL-6 correlated with the alveolar-arterial oxygen tension difference on day 10 and day 30. Plasma KL-6 may be useful as an early marker of chronic lung disease and an indicator of severity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MUC1Humanlung disease severityIEP protein:increased expression:plasmaRGD 
Muc1Ratlung disease severityISOMUC1 (Homo sapiens)protein:increased expression:plasmaRGD 
Muc1Mouselung disease severityISOMUC1 (Homo sapiens)protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc1  (mucin 1, cell surface associated)

Genes (Mus musculus)
Muc1  (mucin 1, transmembrane)

Genes (Homo sapiens)
MUC1  (mucin 1, cell surface associated)


Additional Information