RGD Reference Report - Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study. - Rat Genome Database

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Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study.

Authors: Lee, JS  Rosengart, MR  Kondragunta, V  Zhang, Y  McMurray, J  Branch, RA  Choi, AM  Sciurba, FC 
Citation: Lee JS, etal., Respir Res. 2007 Sep 14;8:64.
RGD ID: 5130900
Pubmed: PMID:17868461   (View Abstract at PubMed)
PMCID: PMC2064925   (View Article at PubMed Central)
DOI: DOI:10.1186/1465-9921-8-64   (Journal Full-text)

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome characterized by varying degrees of airflow limitation and diffusion impairment. There is increasing evidence to suggest that COPD is also characterized by systemic inflammation. The primary goal of this study was to identify soluble proteins in plasma that associate with the severity of airflow limitation in a COPD cohort with stable disease. A secondary goal was to assess whether unique markers associate with diffusion impairment, based on diffusion capacity of carbon monoxide (DLCO), independent of the forced expiratory volume in 1 second (FEV1). METHODS: A cross sectional study of 73 COPD subjects was performed in order to examine the association of 25 different plasma proteins with the severity of lung function impairment, as defined by the baseline measurements of the % predicted FEV1 and the % predicted DLCO. Plasma protein concentrations were assayed using multiplexed immunobead-based cytokine profiling. Associations between lung function and protein concentrations were adjusted for age, gender, pack years smoking history, current smoking, inhaled corticosteroid use, systemic corticosteroid use and statin use. RESULTS: Plasma concentrations of CCL2/monocyte chemoattractant protein-1 (CCL2/MCP-1), CCL4/macrophage inflammatory protein-1 beta (CCL4/MIP-1 beta), CCL11/eotaxin, and interleukin-13 (IL-13) were inversely associated with the % FEV1. Plasma concentrations of soluble Fas were associated with the % DLCO, whereas CXCL9/monokine induced by interferon-gamma (CXCL9/Mig), granulocyte- colony stimulating factor (G-CSF) and IL-13 showed inverse relationships with the % DLCO. CONCLUSION: Systemic inflammation in a COPD cohort is characterized by cytokines implicated in inflammatory cell recruitment and airway remodeling. Plasma concentrations of IL-13 and chemoattractants for monocytes, T lymphocytes, and eosinophils show associations with increasing severity of disease. Soluble Fas, G-CSF and CXCL9/Mig may be unique markers that associate with disease characterized by disproportionate abnormalities in DLCO independent of the FEV1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic obstructive pulmonary disease  IEP 5130900 RGD 
chronic obstructive pulmonary disease  ISOCCL4 (Homo sapiens)5130900; 5130900 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl4  (C-C motif chemokine ligand 4)

Genes (Mus musculus)
Ccl4  (C-C motif chemokine ligand 4)

Genes (Homo sapiens)
CCL4  (C-C motif chemokine ligand 4)


Additional Information