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A dietary supplement improves outcome in an experimental influenza model in old mice.

Authors: Cervi, J  Marotta, F  Bater, C  Masulair, K  Minelli, E  Harada, M  Marandola, P 
Citation: Cervi J, etal., Ann N Y Acad Sci. 2006 May;1067:414-9.
Pubmed: (View Article at PubMed) PMID:16804020
DOI: Full-text: DOI:10.1196/annals.1354.059

Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan-positive cells, lung and plasma lipoperoxides, and TNF-alpha in lung tissue increased during viral infection, but improvement was seen in the MMT-treated group (P < 0.05). MMT also normalized SOD, catalase activities, and ascorbic acid and determined a significant decrease of lung but not nasal viral titer, although nasal inflammatory infiltrate dropped significantly. MMT has potential clinical applications with and has an excellent safety profile even in old animals.


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RGD Object Information
RGD ID: 5130864
Created: 2011-04-13
Species: All species
Last Modified: 2011-04-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.