RGD Reference Report - Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. - Rat Genome Database

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Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.

Authors: Albiger, B  Dahlberg, S  Sandgren, A  Wartha, F  Beiter, K  Katsuragi, H  Akira, S  Normark, S  Henriques-Normark, B 
Citation: Albiger B, etal., Cell Microbiol. 2007 Mar;9(3):633-44. Epub 2006 Sep 27.
RGD ID: 5130710
Pubmed: PMID:17004992   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1462-5822.2006.00814.x   (Journal Full-text)

Toll-like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9-deficient mice have been shown to be more sensitive than wild-type mice to viral, but not to bacterial infections. Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract bacterial infection caused by Streptococcus pneumoniae. Intranasal challenge studies revealed that TLR9 plays a protective role in the lungs at an early stage of infection prior to the entry of circulating inflammatory cells. Alveolar as well as bone marrow-derived macrophages deficient in either TLR9 or the myeloid adaptor differentiation protein MyD88 were impaired in pneumococcal uptake and in pneumococcal killing. Our data suggest that in the airways, pneumococcal infection triggers a TLR9 and MyD88-dependent activation of phagocytic activity from resident macrophages leading to an early clearance of bacteria from the lower respiratory tract.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Pneumococcal Infections  ISOTlr9 (Mus musculus)5130710; 5130710 RGD 
Pneumococcal Infections  IMP 5130710 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR9  (toll like receptor 9)


Additional Information