RGD Reference Report - Role of IgG and complement component C5 in the initial course of experimental cryptococcosis. - Rat Genome Database

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Role of IgG and complement component C5 in the initial course of experimental cryptococcosis.

Authors: Dromer, F  Perronne, C  Barge, J  Vilde, JL  Yeni, P 
Citation: Dromer F, etal., Clin Exp Immunol. 1989 Dec;78(3):412-7.
RGD ID: 5130160
Pubmed: PMID:2612053   (View Abstract at PubMed)
PMCID: PMC1534827   (View Article at PubMed Central)

Although cellular immunity has a crucial role during cryptococcosis, several in vitro studies have pointed out the importance of IgG anti-Cryptococcus neoformans antibodies and complement components during phagocytosis of the yeast by polymorphonuclear leucocytes and monocytes. We investigated the role of complement and specific antibodies in host defences against experimental cryptococcosis, using a monoclonal IgG1 antibody (E1) specific for cryptococcal capsular polysaccharide, and mice congenitally sufficient or deficient in the fifth component of complement (C5). During in vitro experiments, E1 and the normal mouse serum from C5-sufficient and -deficient mice were unable to inhibit the growth of C.neoformans. However, E1 was an efficient opsonin for the ingestion of C. neoformans by mouse peritoneal macrophages, acting in synergy with normal mouse serum. In vivo, E1 was protective in heavily infected C5-deficient mice (DBA/2) dying from an early acute pneumonia, but not in C5-sufficient mice (BALB/c) and in DBA/2 mice infected with a smaller inoculum dying from a late progressive meningo-encephalitis. Although protection against pneumonia is attributed to a local recruitment of phagocytes in C5-sufficient mice, this was not observed in C5-deficient mice protected with E1. In this case, IgG anti-C. neoformans antibodies seem to be an alternative for an efficient opsonization of the yeasts. Altogether, these data suggest that two main mechanisms may protect infected mice from an early fatal pneumonia: the efficient opsonization of the yeast by complement and the recruitment of phagocytes in infected tissues.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
C5RatFungal Lung Diseases  ISOHc (Mus musculus) RGD 
C5HumanFungal Lung Diseases  ISOHc (Mus musculus) RGD 
HcMouseFungal Lung Diseases  IAGP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
C5  (complement C5)

Genes (Mus musculus)
Hc  (hemolytic complement)

Genes (Homo sapiens)
C5  (complement C5)


Additional Information