RGD Reference Report - Cytochrome c: functions beyond respiration. - Rat Genome Database

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Cytochrome c: functions beyond respiration.

Authors: Ow, YP  Green, DR  Hao, Z  Mak, TW 
Citation: Ow YP, etal., Nat Rev Mol Cell Biol. 2008 Jul;9(7):532-42.
RGD ID: 5130000
Pubmed: PMID:18568041   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm2434   (Journal Full-text)

Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family. As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions.


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