RGD Reference Report - The logic of TGFbeta signaling. - Rat Genome Database

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The logic of TGFbeta signaling.

Authors: Massague, J  Gomis, RR 
Citation: Massague J and Gomis RR, FEBS Lett. 2006 May 22;580(12):2811-20. Epub 2006 Apr 21.
RGD ID: 5129861
Pubmed: PMID:16678165   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2006.04.033   (Journal Full-text)

The identification of the TGFbeta cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.


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