RGD Reference Report - Notch signaling: control of cell communication and cell fate. - Rat Genome Database

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Notch signaling: control of cell communication and cell fate.

Authors: Lai, EC 
Citation: Lai EC Development. 2004 Mar;131(5):965-73.
RGD ID: 5129787
Pubmed: PMID:14973298   (View Abstract at PubMed)
DOI: DOI:10.1242/dev.01074   (Journal Full-text)

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.


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