RGD Reference Report - Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia. - Rat Genome Database

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Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia.

Authors: Hirata, K  Sugama, Y  Ikura, Y  Ohsawa, M  Inoue, Y  Yamamoto, S  Kitaichi, M  Ueda, M 
Citation: Hirata K, etal., Int J Mol Med. 2007 Apr;19(4):565-70.
RGD ID: 5128816
Pubmed: PMID:17334631   (View Abstract at PubMed)

Previous studies have shown that mast cell chymase induces and promotes fibrogenesis in injured tissues. We studied the roles of mast cell chymase in the fibritic processes of human idiopathic interstitial pneumonias. Frozen tissue sections from human lungs with usual interstitial pneumonia (n=7), nonspecific interstitial pneumonia (n=4) and normal lungs (n=10) were studied immunohistochemically. Monoclonal antibodies against mast cell chymase, tryptase, interleukin-4, and smooth muscle actin were used. Stained cells or areas were quantified by computer-aided morphometry. The numbers of both tryptase-positive mast cells and chymase-positive mast cells were significantly greater in lung tissues with idiopathic interstitial pneumonia than in normal lung tissues. The increase in the number of chymase-positive mast cells in the diseased lung tissues was closely related to an increase in interleukin-4-positive cells, and also to an accumulation of smooth muscle cells and myofibroblasts. Because smooth muscle cell and myofibroblast proliferation is a principal pathological change in idiopathic interstitial pneumonias, these observations suggest that mast cell chymase, possibly induced by interleukin-4-dependent phenotypic modulation, may be an important mediator in the inflammatory and fibrotic processes of idiopathic interstitial pneumonia in humans.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
interstitial lung disease  IEP 5128816protein:increased expression:lung and mast cell (human)RGD 
interstitial lung disease  ISOCMA1 (Homo sapiens)5128816; 5128816protein:increased expression:lung and mast cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cma1  (chymase 1)

Genes (Mus musculus)
Cma1  (chymase 1, mast cell)

Genes (Homo sapiens)
CMA1  (chymase 1)


Additional Information