RGD Reference Report - High-affinity immunoglobulin E receptor expression is increased in large and small airways in fatal asthma. - Rat Genome Database

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High-affinity immunoglobulin E receptor expression is increased in large and small airways in fatal asthma.

Authors: Den Otter, I  Silva, LF  Carvalho, AL  Pires-Neto, RC  Annoni, R  Ferreira, DS  Bajema, I  Van Schadewijk, A  Rabe, KF  Dolhnikoff, M  Sterk, PJ  Hiemstra, PS  Mauad, T 
Citation: den Otter I, etal., Clin Exp Allergy. 2010 Oct;40(10):1473-81. doi: 10.1111/j.1365-2222.2010.03576.x.
RGD ID: 5128717
Pubmed: PMID:20937062   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2222.2010.03576.x   (Journal Full-text)

BACKGROUND: IgE and its high-affinity receptor FcvarepsilonRI play an important role in allergy and asthma. The distribution of FcvarepsilonRI expression in the airways and within the airway wall, however, is largely unknown. OBJECTIVE: In this study, we aimed to map the distribution of FcvarepsilonRI in different layers of large airways (LA) and small airways (SA) in lung tissue from non-smoking and smoking patients who died of asthma [fatal asthma (FA)] and non-smoking controls (CTR). METHODS: Postmortem lung tissue from 24 cases of non-smoking FA, 13 smoking FA patients and from 19 subjects who died of non-pulmonary causes (CTR) was immunohistochemically stained for FcvarepsilonRI and AA1 (mast cell tryptase marker). The expression of these markers was analysed in inner, muscle, and outer layers of both LA and SA by image analysis. RESULTS: FcvarepsilonRI expression was higher in non-smoking and smoking FA compared with CTR in the inner and outer layer of SA. In the outer layer of LA, FcvarepsilonRI expression was higher in non-smoking FA compared with CTR. AA1 was higher in non-smoking FA compared with smoking FA and CTR in the outer layer of the SA, which was correlated with FcvarepsilonRI in this layer. CONCLUSION: Our results show that the expression of FcvarepsilonRI is higher in both LA and SA in FA compared with CTR. These differences are predominantly found in the outer layer where they can be attributed in part to the increased mast cell numbers. These results indicate an increased capacity to mount IgE-mediated reactions in FA, both in LA and SA.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma severityIEP 5128717Fatal asthma subjectsRGD 

Objects Annotated

Genes (Homo sapiens)
FCER1A  (Fc epsilon receptor Ia)


Additional Information