RGD Reference Report - Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge. - Rat Genome Database

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Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge.

Authors: Hauber, HP  Bergeron, C  Toda, M  Kontolemos, M  Holroyd, KJ  Levitt, RC  Hamid, Q 
Citation: Hauber HP, etal., Allergy Asthma Clin Immunol. 2007 Mar 15;3(1):19-23. Epub 2007 Mar 15.
RGD ID: 5128687
Pubmed: PMID:20525149   (View Abstract at PubMed)
PMCID: PMC2873628   (View Article at PubMed Central)
DOI: DOI:10.1186/1710-1492-3-1-19   (Journal Full-text)

: Interleukin (IL)-9 is a pleiotropic T helper 2-type cytokine that has been shown to be up-regulated in allergic airway disease, including asthma. IL-9 has been demonstrated to be a potent stimulus for the production and secretion of mucus from airway epithelial cells via induction of a calcium-activated chloride channel, hCLCA1. The objective of this study was to investigate the expression of IL-9 and hCLCA1 following allergen challenge in the nasal mucosa of allergic rhinitis patients. Nasal biopsies were obtained from allergic rhinitis patients out of allergen season both before (baseline) and after local antigen challenge with either ragweed or diluent (control). Immunohistochemistry and in situ hybridization were used to assess IL-9 protein and hCLCA1 messenger ribonucleic acid. Eosinophils and T cells were detected using immunohistochemistry. IL-9 and hCLCA1 were very low at baseline, and expression was significantly up-regulated following ragweed challenge. Whereas the number of eosinophils increased after allergen challenge, T-cell counts did not change significantly. The results of this study demonstrate the relationship between specific allergen challenge and expression of both IL-9 and hCLCA1, suggesting a possible mechanism for the increased production of mucus from airway epithelial cells in allergic rhinitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rhinitis  IEP 5128687 RGD 
rhinitis  ISOIL9 (Homo sapiens)5128687; 5128687 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il9  (interleukin 9)

Genes (Mus musculus)
Il9  (interleukin 9)

Genes (Homo sapiens)
IL9  (interleukin 9)


Additional Information