RGD Reference Report - Role of IL-27-producing dendritic cells in Th1-immunity polarization in Lewis rats. - Rat Genome Database

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Role of IL-27-producing dendritic cells in Th1-immunity polarization in Lewis rats.

Authors: Saito, F  Ohno, Y  Morisawa, K  Kamakura, M  Fukushima, A  Taniguchi, T 
Citation: Saito F, etal., Biochem Biophys Res Commun. 2005 Dec 30;338(4):1773-8. Epub 2005 Nov 2.
RGD ID: 5128497
Pubmed: PMID:16288719   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2005.10.149   (Journal Full-text)

Lewis and Brown Norway rats are entirely different with respect to the polarization of their immune responses (Th1 and Th2, respectively). We found that naive Lewis rat splenocytes treated in vitro with heat-killed Mycobacterium tuberculosis (Mtb) upregulate the expression of both subunits of IL-27 (IL-27p28 and EBI3). Mtb treatment caused naive Lewis rat splenocytes to express 4.6-fold more IL-27p28 than Mtb-treated Brown Norway rat splenocytes 6h after the treatment. Although WSX-1, the IL-27 receptor, was not induced by Mtb treatment in splenocytes from either rat strain, Lewis rats expressed significantly higher levels of the IL-27 signal transducers T-bet and IL-12Rbeta2 than Brown Norway rats. Flow cytometric analysis of dendritic cells from bone marrow cells revealed Lewis rats had more IL-27p28-positive cells. Thus, early in the immune response, Lewis rats appear to produce higher levels of IL-27 than Brown Norway rats, resulting in polarization towards Th1-immunity.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il27Ratresponse to bacterium  IEP  RGD 
Il27Ratresponse to Gram-positive bacterium  IEP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il27Ratcell surface  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)


Additional Information